The biocompatibility of dental materials is a topic of increasing importance for dentists. We investigated the effects of alloys for ceramic crowns and removable prostheses on the skin and lymphoid organs of rats. We used three groups of Sprague Dawley rats: group I as the control, with groups II and III implanted with different biomaterials into subcutaneous pockets. After sacrifice, the rat skin around the implant and the lymph nodes was studied. The tissues of implanted rats were morphologically different from the control animals as they showed a number of mast cells that increased 7 days after the implant with both alloys. These cells decreased 14 days after the implant with alloy for ceramic crowns whereas they were still high 28 days after the implant with alloy for removable prostheses. The findings suggest that both alloys induced different and time-dependent inflammatory reactions. Our findings have importance in the future rational design of biocompatible implantable and blood-contact biomaterials.