Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates

J Med Chem. 2004 Dec 16;47(26):6649-52. doi: 10.1021/jm040802v.

Abstract

Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects
  • Escherichia coli / metabolism
  • Escherichia coli / radiation effects
  • Light
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology
  • Polylysine / chemical synthesis*
  • Polylysine / chemistry
  • Polylysine / pharmacology
  • Porphyrins / chemical synthesis*
  • Porphyrins / chemistry
  • Porphyrins / pharmacology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / metabolism
  • Staphylococcus aureus / radiation effects
  • Stereoisomerism
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Photosensitizing Agents
  • Porphyrins
  • Polylysine