Abstract
A conformationally restricted cyclic pentapeptide, containing an unsaturated 9-membered lactam as a semi-rigid scaffold, was prepared in a very convergent manner, through tandem Ugi reaction/ring closing metathesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Cyclization
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Models, Molecular
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Protein Conformation
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Stereoisomerism