UK-2A, B, C and D, novel antifungal antibiotics from streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells

J Antibiot (Tokyo). 2004 Oct;57(10):687-90. doi: 10.7164/antibiotics.57.687.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimycin A / chemistry
  • Antimycin A / pharmacology*
  • Cell Line
  • Kidney Tubules, Proximal / drug effects*
  • Kidney Tubules, Proximal / metabolism
  • Lactones / chemistry
  • Lactones / pharmacology*
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Reactive Oxygen Species / metabolism*
  • Structure-Activity Relationship
  • Swine

Substances

  • Lactones
  • Pyridines
  • Reactive Oxygen Species
  • UK 2A
  • Antimycin A