Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol

Trans R Soc Trop Med Hyg. 1992 Jan-Feb;86(1):31-3. doi: 10.1016/0035-9203(92)90427-e.

Abstract

The electrocardiographic (ECG) changes in Bolivian patients with mucocutaneous leishmaniasis, treated with meglumine antimoniate and allopurinol, were evaluated. Electric changes due to the antimonial compound appeared in 45% of the patients, and consisted of repolarization alteration, principally affecting the T wave and the S-T segment. The changes disappeared within 2 months following the end of the antimonial treatment. In patients with associated Chagas disease and leishmaniasis, antimonial therapy did not aggravate the ECG changes characteristic of Chagasic cardiopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Allopurinol / therapeutic use*
  • Antiprotozoal Agents / therapeutic use*
  • Chagas Cardiomyopathy / physiopathology
  • Chagas Disease / complications
  • Electrocardiography / drug effects*
  • Female
  • Humans
  • Leishmaniasis, Mucocutaneous / complications
  • Leishmaniasis, Mucocutaneous / drug therapy*
  • Leishmaniasis, Mucocutaneous / physiopathology
  • Male
  • Meglumine / therapeutic use*
  • Meglumine Antimoniate
  • Middle Aged
  • Organometallic Compounds / therapeutic use*

Substances

  • Antiprotozoal Agents
  • Organometallic Compounds
  • Allopurinol
  • Meglumine
  • Meglumine Antimoniate