Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor

Pär Holmberg; Lars Tedenborg; Susanne Rosqvist; Anette M Johansson

doi:10.1016/j.bmcl.2004.11.013

Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor

Bioorg Med Chem Lett. 2005 Feb 1;15(3):747-50. doi: 10.1016/j.bmcl.2004.11.013.

Authors

Pär Holmberg¹, Lars Tedenborg, Susanne Rosqvist, Anette M Johansson

Affiliation

¹ Organic Pharmaceutical Chemistry, Uppsala University, PO Box 574, SE-751 23 Uppsala, Sweden.

PMID: 15664850
DOI: 10.1016/j.bmcl.2004.11.013

Abstract

The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT(7) receptor affinities that varies from nM to muM, indicating that this small set of derivatives constitute a novel and interesting starting point for further structure-serotonin 5-HT(7) activity relationship (SAR) studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Chromans / chemical synthesis*
Chromans / pharmacology
Humans
Models, Molecular
Molecular Structure
Radioligand Assay
Receptors, Serotonin / chemistry*
Receptors, Serotonin / metabolism
Serotonin Receptor Agonists / chemical synthesis
Structure-Activity Relationship

Substances

Chromans
Receptors, Serotonin
Serotonin Receptor Agonists
serotonin 7 receptor