1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents

Bioorg Med Chem Lett. 2005 Feb 1;15(3):809-12. doi: 10.1016/j.bmcl.2004.10.094.

Abstract

A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A-I-elevating agents. Derivatives 5h, 7j, 7n, and 7o were found to be as effective or superior to gemfibrozil.

MeSH terms

  • Animals
  • Apolipoprotein A-I / blood
  • Apolipoprotein A-I / drug effects
  • Cholesterol / administration & dosage
  • Cholesterol / blood
  • Humans
  • Lipids / blood
  • Lipoproteins, HDL / blood
  • Lipoproteins, HDL / drug effects*
  • Male
  • Phenylthiourea / analogs & derivatives*
  • Phenylthiourea / chemical synthesis
  • Phenylthiourea / pharmacology*
  • Rats
  • Structure-Activity Relationship
  • Weight Gain / drug effects

Substances

  • Apolipoprotein A-I
  • Lipids
  • Lipoproteins, HDL
  • Phenylthiourea
  • Cholesterol