Hemochromatosis mutations in Iranians with hepatitis B virus infection

Clin Infect Dis. 2005 Feb 1;40(3):e19-21. doi: 10.1086/426143. Epub 2004 Dec 29.

Abstract

In this study, the frequencies of the common hemochromatosis gene mutations were assessed in 75 Iranian subjects with chronic hepatitis B infection. We found that the major C282Y mutation was significantly more frequent in subjects infected with hepatitis B virus (4%) than in 194 control subjects (0%, P=.02; Fisher's exact test).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Female
  • Genetic Predisposition to Disease
  • Hemochromatosis / complications*
  • Hemochromatosis / genetics*
  • Hemochromatosis Protein
  • Hepatitis B, Chronic / complications*
  • Hepatitis B, Chronic / genetics
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Iran
  • Male
  • Membrane Proteins / genetics*
  • Mutation / genetics*

Substances

  • HFE protein, human
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I
  • Membrane Proteins