Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

FEBS Lett. 2005 Feb 7;579(4):859-62. doi: 10.1016/j.febslet.2004.11.036.

Abstract

The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis
  • Chromosome Aberrations
  • DNA-Binding Proteins
  • Humans
  • Neoplasms / metabolism
  • Telomerase / chemistry
  • Telomerase / metabolism
  • Telomerase / physiology*
  • Telomere / genetics
  • Telomere / metabolism*

Substances

  • DNA-Binding Proteins
  • Telomerase