Renal handling of endothelin in patients with chronic heart failure

Am J Cardiol. 2005 Feb 15;95(4):532-4. doi: 10.1016/j.amjcard.2004.10.027.

Abstract

Chronic heart failure is characterized by increased renal extraction of endothelin (ET)-1 and unaltered handling of big ET-1. The renal extraction of ET-1 in patients with heart failure is closely related to elevations in pulmonary artery and pulmonary capillary wedge pressures.

Publication types

  • Comparative Study

MeSH terms

  • Blood Pressure / physiology
  • Endothelins / blood*
  • Heart Failure / blood*
  • Heart Failure / physiopathology
  • Humans
  • Kidney / blood supply
  • Kidney / metabolism*
  • Kidney / physiopathology
  • Middle Aged
  • Pulmonary Wedge Pressure / physiology
  • Regional Blood Flow / physiology
  • Renal Circulation / physiology

Substances

  • Endothelins