Production of [17F]CH3F (t1/2=65 s), an improved PET tracer for rCBF measurement

Appl Radiat Isot. 2005 Apr;62(4):525-32. doi: 10.1016/j.apradiso.2004.08.044.

Abstract

Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cerebrovascular Circulation
  • Fluorine Radioisotopes / chemistry*
  • Humans
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Isotope Labeling / methods*
  • Positron-Emission Tomography / methods

Substances

  • Fluorine Radioisotopes
  • Hydrocarbons, Fluorinated
  • fluoromethane