Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing

J Cardiovasc Electrophysiol. 2005 Feb;16(2):217-20. doi: 10.1046/j.1540-8167.2004.40411.x.

Abstract

Spontaneous T wave alternans in Brugada syndrome. A 43-year-old man with an episode of syncope showed ECG patterns of coved-type ST elevation in leads V1-V3 and right bundle branch block pattern. The patient had spontaneous T wave alternans at baseline, and T wave alternans diminished with distinct development of ST elevation after administration of Na+ channel blocker, and during oral glucose load and atrial pacing. Na+ channel mutation may contribute to the genesis of his ECG changes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Arrhythmia Agents / administration & dosage*
  • Bundle-Branch Block / physiopathology*
  • Bundle-Branch Block / therapy*
  • Cardiac Pacing, Artificial
  • Death, Sudden, Cardiac
  • Electrocardiography*
  • Flecainide / therapeutic use
  • Glucose Tolerance Test*
  • Humans
  • Male
  • Sodium Channel Blockers / therapeutic use
  • Syndrome

Substances

  • Anti-Arrhythmia Agents
  • Sodium Channel Blockers
  • Flecainide