Abstract
Demyelination events or multiple sclerosis following hepatitis B virus (HBV) vaccination have been reported. We therefore compared the T-cell response to HBsAg in patients with CNS demyelination following HBV vaccination and in HBV-vaccinated healthy individuals. Our data showed no differences in terms of T-cell proliferation or cytokine production between these groups and may help to allay concerns that HBV vaccination might trigger a deleterious immune response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cell Proliferation
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Central Nervous System / immunology*
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Central Nervous System / pathology*
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Cytokines / biosynthesis
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Cytokines / immunology
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Cytokines / metabolism
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Demyelinating Autoimmune Diseases, CNS / etiology
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Demyelinating Autoimmune Diseases, CNS / immunology*
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Demyelinating Autoimmune Diseases, CNS / pathology
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Female
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Hepatitis B / immunology*
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Hepatitis B Vaccines / adverse effects*
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Hepatitis B Vaccines / immunology*
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Hepatitis B virus / immunology
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Humans
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Male
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Middle Aged
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Myelin Sheath / metabolism
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
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Vaccination / adverse effects*
Substances
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Cytokines
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Hepatitis B Vaccines