Stereoselective synthesis of multisubstituted alkenes via conformationally labile alkenyllithium species

Org Lett. 2005 Mar 3;7(5):909-11. doi: 10.1021/ol050114l.

Abstract

Stereoselective synthesis of tri- and tetrasubstituted alkenylsilanes has been realized by the selective intramolecular silicon migration in the rapidly equilibrating alkenyllithium species. Subsequent copper- and palladium-mediated coupling with allyl and aryl halides provides tri- and tetrasubstituted alkenes possessing all different carbon-substituents with complete stereoselectivity. [structure: see text]