mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis

Antimicrob Agents Chemother. 2005 Mar;49(3):1216-9. doi: 10.1128/AAC.49.3.1216-1219.2005.

Abstract

A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology*
  • Methicillin Resistance*
  • Oxacillin / pharmacology
  • Phenotype
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sigma Factor / physiology*
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / genetics
  • Transcription, Genetic

Substances

  • Bacterial Proteins
  • MecA protein, Staphylococcus epidermidis
  • SigB protein, Bacteria
  • Sigma Factor
  • Oxacillin