Abstract
A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Indoles / chemical synthesis*
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Indoles / pharmacology*
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Neoplasms / drug therapy
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Triazines / chemical synthesis*
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Triazines / pharmacology*
Substances
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Antineoplastic Agents
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Indoles
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Triazines