Abstract
The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. The PPARgamma agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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DNA, Complementary / biosynthesis
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DNA, Complementary / genetics
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Drug Design
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Fibroblasts / metabolism
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Genetic Vectors
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / pharmacology
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mice
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PPAR gamma / genetics
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Plasmids
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Quercetin / analogs & derivatives*
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Quercetin / chemical synthesis*
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Quercetin / pharmacology
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Transfection
Substances
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DNA, Complementary
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Hypoglycemic Agents
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Indicators and Reagents
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PPAR gamma
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Quercetin