The multi-objective frequency processing installed in the FCR5000R (Fuji Film Medical) is superior to the conventional processing used in the FCR9000 (Fuji Film Medical) in evaluating frequency processing. A suitable combination of parameters for multi-frequency-processing in computed radiography (CR) mammography was evaluated. The paired-comparison method using phantom images was performed for the visual evaluation. Results showed that the evaluation score of mass and fiber lesions depended on the multi-frequency balance type (MRB) parameter, and the low-frequency-cycle emphasizing parameter had the highest score. In contrast, the score of microcalcifications depended on the degree of multi-frequency enhancement (MRE). The most suitable parameters for the multi-frequency processing of every size and type of breast lesion were not obtained. However, MRB=A, MRT=p, and MRE=1.0 can be recommend for CR mammography.