Abstract
[reaction: see text] The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Combinatorial Chemistry Techniques*
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Enterococcus faecalis / metabolism
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Enterococcus faecium / metabolism
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Genetic Engineering
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Glucosyltransferases / metabolism*
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Glycopeptides / chemistry*
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Methicillin Resistance / physiology
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Molecular Structure
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Salmonella / metabolism
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Staphylococcus aureus / metabolism
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Vancomycin* / analogs & derivatives
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Vancomycin* / chemical synthesis
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Vancomycin* / chemistry
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Vancomycin* / pharmacology
Substances
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Glycopeptides
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Vancomycin
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Glucosyltransferases
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glucosyltransferase E