A conserved HLA B13-restricted cytotoxic T lymphocyte epitope in Nef is a dominant epitope in HLA B13-positive HIV-1-infected patients

AIDS. 2005 Apr 29;19(7):734-5. doi: 10.1097/01.aids.0000166099.36638.56.

Abstract

We report on the first HLA B13-restricted minimal cytotoxic T lymphocyte (CTL) epitope RQDILDLWI (RI9, amino acids 106-114 in HIV-1 Nef). In most patients the frequency of RI9-specific CTL exceeded the number of CTL against other epitopes, indicating that RI9 is a dominant epitope in HLA B13-positive patients. Targeting this conserved Nef epitope may be an important factor for the published association of HLA B13 with a favourable course of HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Consensus Sequence
  • Cytotoxicity, Immunologic
  • Epitope Mapping
  • Epitopes, T-Lymphocyte*
  • Gene Products, nef*
  • HIV Infections / immunology*
  • HIV Infections / mortality
  • HIV-1 / immunology*
  • HIV-1 / isolation & purification
  • HLA-B Antigens*
  • HLA-B13 Antigen
  • Humans
  • Immunodominant Epitopes
  • Survival Rate
  • T-Lymphocytes, Cytotoxic / immunology*
  • nef Gene Products, Human Immunodeficiency Virus

Substances

  • Epitopes, T-Lymphocyte
  • Gene Products, nef
  • HLA-B Antigens
  • HLA-B13 Antigen
  • Immunodominant Epitopes
  • nef Gene Products, Human Immunodeficiency Virus