Abstract
Liquid chromatographic separation of enantiomers was accomplished using a chiral stationary phase (CSP) derived from (S)-biotin on silica gel. In both nonaqueous and aqueous media, this CSP (1) permitted separation of racemic amino acid derivatives based on hydrogen bonding with a urea moiety of the biotin moiety.
MeSH terms
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Amino Acids / isolation & purification*
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Biotin / chemistry*
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Chromatography, Liquid / instrumentation
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Chromatography, Liquid / methods*
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Dinitrobenzenes / chemistry
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Dinitrobenzenes / isolation & purification
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Hydrogen Bonding
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Isomerism
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Silica Gel
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Silicon Dioxide / chemistry
Substances
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Amino Acids
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Dinitrobenzenes
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Silica Gel
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Biotin
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Silicon Dioxide