[Magnetic resonance tomogography after cryotherapy of long bones in an animal model]

Rofo. 2005 Apr;177(4):564-8. doi: 10.1055/s-2005-857905.
[Article in German]

Abstract

Purpose: To describe the MR findings following cryoablation of long bones.

Materials and method: Cryoablation was performed in femoral and tibial bones of 24 sheep under general anesthesia. MRI of the treated and untreated contralateral bones was performed immediately thereafter and at 2, 4 and 6 months after the cryosurgical procedure.

Results: On the MRI performed immediately after cryotherapy, the lesions showed low signal intensities relative to the normal bone marrow on unenhanced T1- and T2-weighted images. At 2, 4 and 6 months after cryoablation, the lesions showed high signal intensities on STIR images, low signal intensities on T1-weighted and heterogeneous enhancement on contrast-enhanced T1-weighted MR images. The femoral lesions decreased in size from 31 +/- 3 mm immediately after the cryotherapy to 13 +/- 4 mm 6 month later and the tibial lesions from 29 +/- 7 mm to 19 +/- 4 mm.

Conclusion: MRI shows bone marrow lesions immediately after cryotherapy and can easily monitor healing lesions. MR imaging is suitable for following cryotherapy.

Publication types

  • Evaluation Study
  • Validation Study

MeSH terms

  • Animals
  • Cryotherapy / methods*
  • Disease Models, Animal
  • Femoral Neoplasms / diagnosis*
  • Femoral Neoplasms / therapy*
  • Magnetic Resonance Imaging / methods*
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sheep
  • Treatment Outcome