Spectral characteristics of the supramolecular complexes of polypyrrolic sensitizers and cyclodextrin carriers: usage in photodynamic therapy of tumors

Acta Medica (Hradec Kralove). 2004;47(4):309-11.

Abstract

The objective of our work was to describe the photophysical properties (absorption and fluorescence) of the sensitizers TPPS4, ZnTPPS4 a PdTPPS4 and above all the complexes of these sensitizers with cyclodextrin carriers HP-alpha-CD, HP-beta-CD and HP-gamma-CD (2-hydroxypropyl-alpha, beta, gamma-cyclodextrin) in a suitable environment for the cultivation of cancerous cell lines, and to determine the optimal radioactive conditions for maximizing photodynamic effects in cancerous cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclodextrins / chemistry*
  • Drug Carriers / chemistry*
  • Neoplasms / drug therapy
  • Photochemistry
  • Photochemotherapy*
  • Polymers / chemistry
  • Porphyrins / chemistry
  • Pyrroles / chemistry
  • Radiation-Sensitizing Agents / chemistry*
  • Spectrometry, Fluorescence
  • Spectrophotometry

Substances

  • Cyclodextrins
  • Drug Carriers
  • Polymers
  • Porphyrins
  • Pyrroles
  • Radiation-Sensitizing Agents
  • polypyrrole