Abstract
Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anthozoa / chemistry*
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / isolation & purification*
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Bridged-Ring Compounds / pharmacology
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Crystallography, X-Ray
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Resistance
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Conformation
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Molecular Structure
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Pacific Ocean
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Panama
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Plasmodium falciparum / drug effects*
Substances
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Bridged-Ring Compounds
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Diterpenes
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Furans
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Lactones
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furanocembranolide
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leptolide
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pseudopterolide