Origin and dissemination of chloroquine-resistant Plasmodium falciparum with mutant pfcrt alleles in the Philippines

Antimicrob Agents Chemother. 2005 May;49(5):2102-5. doi: 10.1128/AAC.49.5.2102-2105.2005.

Abstract

The pfcrt allelic type and adjacent microsatellite marker type were determined for 82 Plasmodium falciparum isolates from the Philippines. Mutant pfcrt allelic types P1a and P2a/P2b were dominant in different locations. Microsatellite analysis revealed that P2a/P2b evolved independently in the Philippines, while P1a shared common ancestry with Papua New Guinea chloroquine-resistant parasites.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Antimalarials / pharmacology*
  • Chloroquine / pharmacology*
  • Drug Resistance
  • Humans
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / epidemiology
  • Membrane Proteins / genetics*
  • Membrane Transport Proteins
  • Microsatellite Repeats
  • Philippines / epidemiology
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics*
  • Protozoan Proteins

Substances

  • Antimalarials
  • Membrane Proteins
  • Membrane Transport Proteins
  • PfCRT protein, Plasmodium falciparum
  • Protozoan Proteins
  • Chloroquine