High levels of antimicrobial coresistance among extended-spectrum-beta-lactamase-producing Enterobacteriaceae

Antimicrob Agents Chemother. 2005 May;49(5):2137-9. doi: 10.1128/AAC.49.5.2137-2139.2005.

Abstract

We compared the susceptibility of 312 extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae isolates with that of 1,216 ESBL nonproducers. Of ESBL producers, 25% were susceptible to gentamicin, 30% to trimethoprim-sulfamethoxazole, 41% to ciprofloxacin, and 60% to piperacillin-tazobactam. ESBL nonproducers were more often susceptible to these agents. ESBL-producing Enterobacteriaceae represent a major source of resistance to various antibiotics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross Infection / microbiology
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae Infections / microbiology
  • Hospitals, Teaching
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • beta-Lactamases / metabolism*
  • beta-Lactams / pharmacology

Substances

  • beta-Lactams
  • beta-Lactamases