Abstract
In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actinobacillus Infections / metabolism
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Actinobacillus Infections / pathology
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Actinobacillus pleuropneumoniae / growth & development*
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Actinobacillus pleuropneumoniae / pathogenicity
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Animals
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Bacterial Proteins / physiology*
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Iron / metabolism
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Lung / pathology
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Repressor Proteins / physiology*
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Swine
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Transferrin-Binding Protein B / genetics
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Virulence
Substances
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Bacterial Proteins
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Repressor Proteins
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Transferrin-Binding Protein B
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ferric uptake regulating proteins, bacterial
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Iron