Abstract
The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphibian Proteins / chemical synthesis
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Amphibian Proteins / chemistry
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Amphibian Proteins / metabolism
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Amphibian Proteins / pharmacology*
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Animals
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Antimicrobial Cationic Peptides / chemical synthesis
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Antimicrobial Cationic Peptides / chemistry
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Antimicrobial Cationic Peptides / metabolism
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Antimicrobial Cationic Peptides / pharmacology*
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Colony Count, Microbial
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Drug Interactions
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Drug Resistance, Bacterial
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Cocci / drug effects*
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Gram-Positive Cocci / growth & development*
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Humans
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Microbial Sensitivity Tests
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Skin Diseases, Bacterial / microbiology*
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Soft Tissue Infections / microbiology*
Substances
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Amphibian Proteins
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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citropin 1.1 protein, Litoria