Abstract
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Capsid Proteins / metabolism
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Fragile X Mental Retardation Protein
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Fragile X Syndrome / metabolism
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Gene Products, gag / metabolism
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HIV Infections / metabolism
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HIV-1
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Humans
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Intellectual Disability / metabolism
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Molecular Chaperones / metabolism*
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Nerve Tissue Proteins / metabolism
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Prion Diseases / metabolism
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Prions / metabolism
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Protein Conformation
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RNA / metabolism*
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RNA-Binding Proteins / metabolism
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Structure-Activity Relationship
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Viral Proteins / metabolism
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gag Gene Products, Human Immunodeficiency Virus
Substances
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Capsid Proteins
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FMR1 protein, human
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Gene Products, gag
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Molecular Chaperones
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NCP7 protein, Human immunodeficiency virus 1
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Nerve Tissue Proteins
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Prions
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RNA-Binding Proteins
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Viral Proteins
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gag Gene Products, Human Immunodeficiency Virus
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Fragile X Mental Retardation Protein
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RNA