New water soluble pyrroloquinoline derivatives as new potential anticancer agents

Maria Grazia Ferlin; Christine Marzano; Lisa Dalla Via; Adriana Chilin; Giuseppe Zagotto; Adriano Guiotto; Stefano Moro

doi:10.1016/j.bmc.2005.04.080

New water soluble pyrroloquinoline derivatives as new potential anticancer agents

Bioorg Med Chem. 2005 Aug 1;13(15):4733-9. doi: 10.1016/j.bmc.2005.04.080.

Authors

Maria Grazia Ferlin¹, Christine Marzano, Lisa Dalla Via, Adriana Chilin, Giuseppe Zagotto, Adriano Guiotto, Stefano Moro

Affiliation

¹ Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5-35100 Padova, Italy.

PMID: 15936202
DOI: 10.1016/j.bmc.2005.04.080

Abstract

A new class of water soluble 3H-pyrrolo[3,2-f]quinoline derivatives has been synthesized and investigated as potential anticancer drugs. Water solubility profiles have been used to select the most promising derivatives. The novel compound 10, having two (2-diethylamino-ethyl) side chains linked through positions 3N and 9O, presents a suitable water solubility profile, and it was shown to exhibit cell growth inhibitory properties when tested against the in-house panel of cell lines, in particular those obtained from melanoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Molecular Structure
Pyrroles / chemical synthesis
Pyrroles / chemistry*
Pyrroles / pharmacology*
Quinolines / chemical synthesis
Quinolines / chemistry*
Quinolines / pharmacology*
Solubility
Water / chemistry*

Substances

Antineoplastic Agents
Pyrroles
Quinolines
pyrroloquinoline
Water