Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo

Irina G Meerovich; Victoriav Jerdeva; Valentina M Derkacheva; Gennady A Meerovich; Eugeny A Lukyanets; Eugenia A Kogan; Alexander P Savitsky

doi:10.1016/j.jphotobiol.2004.12.008

Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo

J Photochem Photobiol B. 2005 Jul 1;80(1):57-64. doi: 10.1016/j.jphotobiol.2004.12.008. Epub 2005 Apr 18.

Authors

Irina G Meerovich¹, Victoriav Jerdeva, Valentina M Derkacheva, Gennady A Meerovich, Eugeny A Lukyanets, Eugenia A Kogan, Alexander P Savitsky

Affiliation

¹ Laboratory of Physical Biochemistry, A.N.Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospect, Moscow.

PMID: 15963437
DOI: 10.1016/j.jphotobiol.2004.12.008

Abstract

The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aluminum / pharmacology*
Aluminum / radiation effects*
Animals
Biotin / analogs & derivatives*
Biotin / chemical synthesis
Biotin / pharmacology
Biotinylation*
Carcinoma, Small Cell
Cell Line, Tumor
Cell Survival / drug effects
Cell Survival / radiation effects
Humans
Indoles / chemical synthesis*
Indoles / pharmacology*
Light
Lung Neoplasms
Mice
Photochemotherapy
Photosensitizing Agents / chemical synthesis
Photosensitizing Agents / pharmacology*

Substances

Indoles
Photosensitizing Agents
dibiotinylated aluminum sulfophthalocyanine
Biotin
Aluminum