Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure

Am J Cardiol. 2005 Jul 15;96(2):267-9. doi: 10.1016/j.amjcard.2005.03.057.

Abstract

Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / administration & dosage*
  • Carbazoles / administration & dosage*
  • Carvedilol
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Electrocardiography
  • Female
  • Heart Failure / diagnosis*
  • Heart Failure / drug therapy*
  • Heart Failure / mortality
  • Heart Function Tests
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Propanolamines / administration & dosage*
  • Prospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Survival Rate
  • Treatment Outcome
  • Ventricular Function, Left / drug effects
  • Ventricular Remodeling / drug effects*

Substances

  • Adrenergic beta-Antagonists
  • Carbazoles
  • Propanolamines
  • Carvedilol