Abstract
Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes--natural killer (NK), natural killer T (NKT), and gammadelta T cells--also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Cell Communication / immunology
-
Cell Differentiation / immunology*
-
Dendritic Cells / immunology*
-
Humans
-
Immunity, Cellular*
-
Immunity, Innate*
-
Killer Cells, Natural / immunology
-
Membrane Glycoproteins / immunology
-
Receptors, Antigen, T-Cell, gamma-delta / immunology
-
Receptors, Cell Surface / immunology
-
T-Lymphocytes / immunology
-
Toll-Like Receptors
Substances
-
Membrane Glycoproteins
-
Receptors, Antigen, T-Cell, gamma-delta
-
Receptors, Cell Surface
-
Toll-Like Receptors