Abstract
Objective:
To investigate the effects of HCMV infection on phenotypes of parotid duct epithelial cells and relative mechanisms.
Methods:
The expressions of immediate early antigen of HCMV, pan cytokeratin and cathepsin D etc. were detected by immunohistochemical staining in tissues of parotid cytomegalic inclusion disease.
Results:
Cytokeratin which acts as an epithelial marker became negative while staining of Cathepsin D was intensified in parotid duct epithelial cells after infected by HCMV.
Conclusion:
It demonstrated that cytokeratin was lost through over-expression of Cathepsin D in parotid duct epithelial cells infected by HCMV.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD / analysis
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Antigens, Differentiation, Myelomonocytic / analysis
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Antigens, Viral / analysis
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Cathepsin D / analysis
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Cytomegalovirus / immunology
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Cytomegalovirus / physiology*
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Cytomegalovirus Infections / metabolism
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Cytomegalovirus Infections / pathology
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Cytomegalovirus Infections / virology*
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Desmin / analysis
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Epithelial Cells / metabolism
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Epithelial Cells / pathology
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Epithelial Cells / virology*
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Female
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Glial Fibrillary Acidic Protein / analysis
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Host-Pathogen Interactions
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Humans
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Immunohistochemistry
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Infant
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Keratins / analysis
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Male
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Mice
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Salivary Ducts / metabolism
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Salivary Ducts / pathology
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Salivary Ducts / virology*
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Vimentin / analysis
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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Antigens, Viral
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CD68 antigen, human
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Desmin
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Glial Fibrillary Acidic Protein
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Vimentin
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Keratins
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Cathepsin D