1,4-benzoxazin-3-one, 2-benzoxazolinone and gallic acid from Calceolaria thyrsiflora Graham and their antibacterial activity

Z Naturforsch C J Biosci. 2005 May-Jun;60(5-6):389-93. doi: 10.1515/znc-2005-5-604.

Abstract

Secondary metabolites, DIBOA, HBOA, 7-OH-HBOA, BOA and gallic acid, were isolated and quantified from Calceolaria thyrsiflora Graham, a native medicinal plant of Chile belonging to the Scrophulariaceae family. The highest DIBOA contents were determined in leaves (145 mmol kg(-1) dry wt) and flowers (161 mmol kg(-1) dry wt). Antibacterial activities of DIBOA, HBOA, BOA, gallic acid and infusions of flowers and leaves were determined. The phytomedicinal properties attributed to C. thyrsiflora Graham could be understood on the basis of its antibacterial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Benzoxazines / chemistry*
  • Benzoxazines / isolation & purification
  • Benzoxazines / pharmacology
  • Benzoxazoles / chemistry*
  • Benzoxazoles / isolation & purification
  • Escherichia coli / drug effects
  • Flowers / chemistry
  • Gallic Acid / chemistry*
  • Gallic Acid / isolation & purification
  • Gallic Acid / pharmacology
  • Microbial Sensitivity Tests
  • Oxazines / chemistry
  • Oxazines / isolation & purification
  • Oxazines / pharmacology
  • Phytotherapy
  • Plant Leaves / chemistry
  • Scrophulariaceae / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • 2-hydroxy-1,4-benzoxazin-3-one
  • Anti-Bacterial Agents
  • Benzoxazines
  • Benzoxazoles
  • Oxazines
  • benzoxazolone
  • 2,4-dihydroxy-1,4-benzoxazin-3-one
  • Gallic Acid