Changing distribution of group A rotavirus G-types and genetic analysis of G9 circulating in Japan

Arch Virol. 2006 Jan;151(1):183-92. doi: 10.1007/s00705-005-0604-z. Epub 2005 Aug 8.

Abstract

A total of 1,797 fecal specimens from infants and children with acute gastroenteritis in Japan from July 2000 to June 2003 were tested for group A rotavirus by ELISA, RT-PCR, RNA-PAGE and latex agglutination methods. Of these, 439 were found to be positive for group A rotavirus and this presented 24.4%. In 2000-2001, G1 was the most prevalent (45.5%) followed by G2 (32.5%), G3 (12.3%), G9 (5.9%) and G4 (2.6%). However, G2 was found predominant with 40% in the following year (2001-2002). Interestingly, G9 had a rapid increase of infection up to 17.8%. In 2002-2003, G3 dominated over other G-types with 34%. Another interesting feature of the study was the demonstration of great genetic diversity among G9 strains in Japan. Worth of note was the first prevalence pattern of rotavirus G-types with an increase of G2, G3 as well as G9 and a decrease of G1 during the 20 year-survey of rotavirus infection in Japan.

Publication types

  • Comparative Study
  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral / genetics*
  • Capsid Proteins / genetics*
  • Child
  • Child, Preschool
  • Feces / virology
  • Gastroenteritis / epidemiology
  • Gastroenteritis / virology
  • History, 21st Century
  • Humans
  • Infant
  • Japan / epidemiology
  • Rotavirus / genetics*
  • Rotavirus / isolation & purification
  • Rotavirus Infections / epidemiology*
  • Rotavirus Infections / genetics
  • Rotavirus Infections / history
  • Rotavirus Infections / virology
  • Sequence Homology, Amino Acid
  • Serotyping

Substances

  • Antigens, Viral
  • Capsid Proteins
  • VP7 protein, Rotavirus