Abstract
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Ligands
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Protein Binding
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Rats
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Receptors, Nicotinic / metabolism
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Structure-Activity Relationship
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Tropanes / chemical synthesis*
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Tropanes / metabolism
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Tropanes / pharmacology*
Substances
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Ligands
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Receptors, Nicotinic
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Tropanes