Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses

J Theor Biol. 2006 Feb 21;238(4):754-63. doi: 10.1016/j.jtbi.2005.06.021. Epub 2005 Aug 22.

Abstract

Using computer simulations of a mathematical model for the regulation of stem cell and neutrophil production in dogs, we have studied the efficacy of four different treatment protocols for cyclical neutropenia involving granulocyte colony stimulating factor (G-CSF). The first treatment scheme is based on the bifurcation analysis of the mathematical model and proposes a daily, phase-dependent, protocol. The second involves alternate day administration of G-CSF. The third triggers G-CSF administration whenever neutrophil levels fall below a predetermined level, and the fourth one follows a random administration protocol. The computer simulations predict that clinically desirable results can be achieved with the three last methods, using far less G-CSF than would be needed with the standard daily treatment. If the results of this modelling are borne out clinically, they will entail a considerable financial savings for patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Cost-Benefit Analysis
  • Dogs
  • Drug Administration Schedule
  • Drug Costs
  • Granulocyte Colony-Stimulating Factor / administration & dosage*
  • Granulocyte Colony-Stimulating Factor / economics
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Models, Biological*
  • Neutropenia / drug therapy*
  • Neutropenia / economics

Substances

  • Granulocyte Colony-Stimulating Factor