Abstract
Amides, 2 and 3 related to the potent antifungal triazole-amide 3-acylamino-2-aryl-1-triazolyl-butanol(1) were synthesized starting from the triazole-alcohol 6. The antifungal activity of 2 and 3 against a mouse systemic Candida albicans infection was found to be less potent than that of 1.
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / therapeutic use
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Candidiasis / drug therapy*
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Chlorobenzenes / chemical synthesis*
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Chlorobenzenes / chemistry
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Chlorobenzenes / pharmacology
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Mice
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Structure-Activity Relationship
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology
Substances
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Antifungal Agents
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Chlorobenzenes
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Triazoles