ALK positive inflammatory myofibroblastic tumour of the pineal region

J Clin Pathol. 2005 Sep;58(9):981-3. doi: 10.1136/jcp.2004.022947.

Abstract

Inflammatory myofibroblastic tumours (IMTs) are an uncommon spindle cell neoplasm with a dense inflammatory infiltrate, usually encountered in children. IMTs of the central nervous system are extremely rare. This report describes the case of an IMT in a 61 year old man, in the pineal region. The tumour was completely excised, and immunohistochemistry demonstrated anaplastic lymphoma kinase 1 expression. There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour.

Publication types

  • Case Reports

MeSH terms

  • Anaplastic Lymphoma Kinase
  • Brain Neoplasms / enzymology*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Muscle Tissue / enzymology*
  • Neoplasms, Muscle Tissue / surgery
  • Pineal Gland*
  • Protein-Tyrosine Kinases / metabolism*
  • Receptor Protein-Tyrosine Kinases

Substances

  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases