No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females

Neurosci Lett. 2005 Dec 9;389(3):121-3. doi: 10.1016/j.neulet.2005.03.075.

Abstract

Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Previous studies have demonstrated a significant association between MAO-A gene polymorphism and personality traits in males. The purpose of the present study was to examine this association in females. The subjects were 219 healthy Japanese females. We genotyped a variable number of tandem repeats located upstream of the MAO-A gene. Personality traits were assessed using the Temperament and Character Inventory (TCI). There was no association between any personality trait and MAO-A genotype. The present results do not support the hypothesis that MAO-A gene polymorphism is related to certain personality traits in females.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • DNA Mutational Analysis / methods
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Testing / methods
  • Humans
  • Incidence
  • Japan / epidemiology
  • Lung Neoplasms / enzymology*
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / genetics
  • Male
  • Monoamine Oxidase / genetics*
  • Personality / genetics*
  • Personality Inventory
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic / genetics
  • Quantitative Trait, Heritable*
  • Statistics as Topic

Substances

  • Monoamine Oxidase