Effect of granulocyte colony-stimulating factor on kinetics of hemopoietic precursors in regenerating bone marrow

E D Goldberg; A M Dygai; V V Zhdanov; L A Guryantseva; E V Udut; N O Popova; E V Simanina; T Yu Khrichkova

doi:10.1007/s10517-005-0235-0

Effect of granulocyte colony-stimulating factor on kinetics of hemopoietic precursors in regenerating bone marrow

Bull Exp Biol Med. 2005 Jan;139(1):154-7. doi: 10.1007/s10517-005-0235-0.

Authors

E D Goldberg¹, A M Dygai, V V Zhdanov, L A Guryantseva, E V Udut, N O Popova, E V Simanina, T Yu Khrichkova

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.

PMID: 16142300
DOI: 10.1007/s10517-005-0235-0

Abstract

We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors and increased content of DNA-synthesizing CFU-GM in the bone marrow.

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Bone Marrow / drug effects
Bone Marrow / physiology*
Cell Differentiation / drug effects
Cell Proliferation / drug effects
Cyclophosphamide / pharmacology
Granulocyte Colony-Stimulating Factor / pharmacology*
Hematopoietic Stem Cells / drug effects*
Kinetics
Male
Mice
Regeneration*
Stem Cells

Substances

Antineoplastic Agents
Granulocyte Colony-Stimulating Factor
Cyclophosphamide