Abstract
The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allosteric Regulation / drug effects*
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Animals
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COS Cells
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Chlorocebus aethiops
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Cholinesterase Inhibitors / pharmacology*
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Dose-Response Relationship, Drug
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Neurons / drug effects*
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Neurons / physiology
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Patch-Clamp Techniques
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Physostigmine / pharmacology*
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Receptors, Nicotinic / metabolism*
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Time Factors
Substances
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Cholinesterase Inhibitors
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Receptors, Nicotinic
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Physostigmine