Abstract
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Agouti-Related Protein
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Animals
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Anorexia / metabolism
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Arcuate Nucleus of Hypothalamus / cytology*
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Body Weight / drug effects
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Body Weight / physiology
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Cell Count / methods
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Diphtheria Toxin / pharmacology
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Eating / drug effects
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Feeding Behavior / physiology*
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology*
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Intercellular Signaling Peptides and Proteins
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Mice
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Mice, Knockout
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Neurons / drug effects
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Neurons / metabolism*
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Neuropeptide Y / genetics
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Neuropeptide Y / metabolism
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Pro-Opiomelanocortin / deficiency
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Pro-Opiomelanocortin / genetics
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Pro-Opiomelanocortin / metabolism
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Proteins / genetics
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Proteins / metabolism*
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Time Factors
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beta-Galactosidase / biosynthesis
Substances
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Agouti-Related Protein
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Diphtheria Toxin
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Intercellular Signaling Peptides and Proteins
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Neuropeptide Y
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Proteins
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Pro-Opiomelanocortin
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beta-Galactosidase