A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection

Microbiol Immunol. 2005;49(9):853-8. doi: 10.1111/j.1348-0421.2005.tb03674.x.

Abstract

Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy-irradiated (IR) C57BL/6 recipients of B-2 cells from T. gondii-infected C57BL/6 died after infection. B-2 suppressor cells from infected C57BL/6 enhanced production of IL-4 and IL-10 in peritoneal exudate cells (PECs), and down-regulated NO release in peritoneal macrophages after infection. On the other hand, B-2 suppressor cells were not detected in a strain, BALB/c, resistant against infection. These data indicated that irradiation-sensitive B-2 cells regulated susceptibility/resistance in mice against T. gondii infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Disease Models, Animal
  • Disease Susceptibility
  • Immunity, Innate
  • Interleukin-10 / analysis
  • Interleukin-4 / analysis
  • Macrophages / immunology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Nitric Oxide / biosynthesis
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Regulatory / immunology*
  • Toxoplasmosis / immunology*

Substances

  • Interleukin-10
  • Interleukin-4
  • Nitric Oxide