Abstract
In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Arabinofuranosyluracil / analogs & derivatives*
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Arabinofuranosyluracil / pharmacology
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Hepatitis Antigens / analysis
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Hepatitis B Virus, Woodchuck / drug effects*
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Hepatitis B, Chronic / drug therapy*
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Hepatitis B, Chronic / virology
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Hepatitis Delta Virus / drug effects*
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Kinetics
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Marmota
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Pilot Projects
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Time Factors
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United States
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Viremia / drug therapy
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Viremia / prevention & control
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Viremia / virology
Substances
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Antiviral Agents
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Hepatitis Antigens
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Arabinofuranosyluracil
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clevudine