Directional positive selection on an allele of arbitrary dominance

Genetics. 2006 Jan;172(1):713-8. doi: 10.1534/genetics.105.044065. Epub 2005 Oct 11.

Abstract

Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Alleles*
  • Biological Evolution
  • Gene Frequency
  • Genes, Dominant*
  • Genes, Recessive
  • Genetic Variation*
  • Genetics, Population
  • Linkage Disequilibrium
  • Models, Genetic*
  • Polymorphism, Genetic
  • Recombination, Genetic
  • Selection, Genetic*