A new insertion in the HIV-1 reverse transcriptase gene inducing major resistance to non-nucleoside reverse transcriptase inhibitors

AIDS. 2005 Nov 4;19(16):1922-4. doi: 10.1097/01.aids.0000187247.07359.31.

Abstract

We identified an HIV-1 isolate with a 3 base pairs insertion in the 100-105 region of the reverse transcriptase gene (RT) along with a G190E and a V75A mutation. Virus carrying the insertion alone or in association with G190A was not infectious. The association of G190E and the 100-105 insertion displayed a high level of resistance to non-nucleoside reverse transcriptase inhibitors; the addition of the insertion to G190E may increase the activity of RT.

MeSH terms

  • DNA Transposable Elements / genetics
  • DNA, Viral / genetics
  • Drug Resistance, Multiple, Viral / genetics*
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / genetics*
  • Humans
  • Mutation / genetics*
  • Reverse Transcriptase Inhibitors / therapeutic use*

Substances

  • DNA Transposable Elements
  • DNA, Viral
  • Reverse Transcriptase Inhibitors
  • HIV Reverse Transcriptase