Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins

J Am Chem Soc. 2005 Oct 26;127(42):14594-5. doi: 10.1021/ja055957m.

Abstract

The exocyclic DNA base adduct 1,N6-ethenoadenine (epsilonA) is directly repaired by the AlkB proteins in vitro.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / chemistry
  • Adenine / metabolism
  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
  • Alkylation
  • Cytosine / analogs & derivatives
  • Cytosine / chemistry
  • Cytosine / metabolism
  • DNA / chemistry
  • DNA / metabolism
  • DNA Adducts / chemistry
  • DNA Adducts / metabolism*
  • DNA Repair Enzymes
  • DNA Repair*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Dioxygenases
  • Escherichia coli Proteins / chemistry
  • Escherichia coli Proteins / isolation & purification
  • Escherichia coli Proteins / metabolism*
  • Guanine / analogs & derivatives
  • Guanine / chemistry
  • Guanine / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Iron / chemistry
  • Iron / metabolism
  • Mixed Function Oxygenases / chemistry
  • Mixed Function Oxygenases / isolation & purification
  • Mixed Function Oxygenases / metabolism*
  • Molecular Structure
  • Time Factors

Substances

  • 3,N(4)-ethenocytosine
  • DNA Adducts
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • N(2),3-ethenoguanine
  • 1,N(6)-ethenoadenine
  • 1,(N2)-ethenoguanine
  • Guanine
  • Cytosine
  • DNA
  • Iron
  • Mixed Function Oxygenases
  • Dioxygenases
  • ALKBH3 protein, human
  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
  • AlkB protein, E coli
  • DNA Repair Enzymes
  • Adenine