Anticonvulsant-induced chronic pancreatitis. A case report

Ital J Gastroenterol. 1992 Jun;24(5):245-6.

Abstract

We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin. Long-term anticonvulsant drug therapy may have a contributory role in the development of chronic pancreatitis by chronic stimulation of cytochromes P-450.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Carbamazepine / adverse effects
  • Chronic Disease
  • Cytochrome P-450 Enzyme System / metabolism
  • Epilepsy / drug therapy
  • Epilepsy / metabolism
  • Free Radicals / metabolism
  • Humans
  • Male
  • Pancreatitis / chemically induced*
  • Phenytoin / adverse effects
  • Valproic Acid / adverse effects

Substances

  • Anticonvulsants
  • Free Radicals
  • Carbamazepine
  • Valproic Acid
  • Phenytoin
  • Cytochrome P-450 Enzyme System